Phenformin Activates the Unfolded Protein Response in an AMP-activated Protein Kinase (AMPK)-dependent Manner
نویسندگان
چکیده
منابع مشابه
Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.
BACKGROUND The cross-talk between UPR activation and metabolic stress remains largely unclear. RESULTS Phenformin treatment activates the IRE1α and PERK pathways in an AMPK-dependent manner. CONCLUSION AMPK is required for phenformin-mediated IRE1α and PERK activation. SIGNIFICANCE Our findings demonstrate the cross-talk between UPR and metabolic signals. Activation of the unfolded protei...
متن کاملPhenformin Activates Unfolded Protein Response in an AMP-Activated Protein Kinase (AMPK)-Dependent Manner
Activation of unfolded protein response (UPR) is associated with the disruption of endoplasmic reticulum (ER) homeostasis and has been implicated in the pathogenesis of many human metabolic diseases, including obesity and type-2 diabetes. However, the nature of the signals activating UPR under these conditions remains largely unknown. Using a method that we recently optimized to directly measur...
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AMP-activated protein kinase (AMPK) acts as a cellular energy sensor: it responds to an increase in AMP concentration ([AMP]) or the AMP-to-ATP ratio (AMP/ATP). Metformin and phenformin, which are biguanides, have been reported to increase AMPK activity without increasing AMP/ATP. This study tests the hypothesis that these biguanides increase AMPK activity in the heart by increasing cytosolic [...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.462762